演讲摘要：The cerebellum is involved in encoding balance, posture, speed, and gravity during locomotion. However, most studies have been carried out on two-dimensional (2D) ambulation, and little is known about cerebellar activity during free-moving ambulation in a 3D terrain. In the present study, we imaged neuronal activity in the molecular layer of the cerebellum at single-cell resolution while a mouse was walking on a slope in an L maze. We found that >60% of molecular interneurons in the vermis specifically encoded uphill and downhill locomotion during ramp walking irrespective of the horizontal running direction, distance from initial movement position, and slope size. In addition, neuronal activity of a subset of neurons covered entire uphill or downhill positions on the slope. Furthermore, chemogenetic inactivation of the cerebellum impaired the uphill locomotion of mice. Taken together, our results demonstrate that the vermis is crucial for ramp walking, and expand the role of the cerebellum in 3D navigation.
讲者简介：李新建博士于2010年于中国科学院神经所获得博士学位，随后分别在香港理工大学、美国约翰霍普金斯大学和美国国立健康研究所进行研究工作。他丰富的研究经历使他利用果蝇、小鼠、大鼠、狨猴及猕猴在学习记忆、运动控制、神经痛机精神分裂症等多方向进行科学研究。2019年初，李新建博士作为独立的研究员加入浙江大学。其实验室以小型小鼠和非人灵长类动物狨猴为模式动物，通过对皮层神经元单细胞水平钙成像的活动来研究肢体运动的精细控制、语言产生、空间导航、及运动及精神类疾病的神经机制。近些年，李新建博士在Nature, Cell, Advanced Science，National Science Review, Cerebral Cortex, Nature communications,Elife,Advance Materials, Molecule Psychiatric, Sleep, Journal of Neuroscience,等神经科学领域核心期刊发表文章21篇。
首届CCF中国智能汽车学术年会（CIVS 2023）
本期嘉宾
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